MedGenome’s recent paper "A cancer vaccine approach for personalized treatment of Lynch Syndrome" is published in Scientific Reports
FOSTER CITY, CALIFORNIA, UNITED STATES, August 21, 2018 /EINPresswire.com/ — The published study examines the feasibility of treating Lynch syndrome using a personalized cancer vaccine approach by identifying potential immunogenic tumor specific alterations.
Lynch syndrome is a hereditary cancer arising from loss of function mutations in DNA mismatch repair genes, such as MLH1, MSH2, MSH3, MSH6, PMS2, and EPCAM. “Over 1 million Americans are affected by Lynch syndrome according to the Cancer Moonshot Blue Ribbon Panel, wherein only 5% are aware of this” said Prof Henry T. Lynch whose groundbreaking research in 1960s led to the discovery of cancer family syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) also referred to as Lynch syndrome. He also added “Therein, many of these patients are not being advised about its importance nor do they have benefit of colonoscopy and, when indicated, prophylactic colectomy, given the presence of cancer as detected by colonoscopy. And those mismatch repair mutation positive can benefit from prophylactic colectomy and, for women, prophylactic hysterectomy and bilateral salpingo-oophorectomy. I think this clearly enunciates the value, in my opinion, of the mutation that you so meticulously have evaluated”
The MedGenome study reports a large number of potential immunogenic peptides from a Lynch syndrome-affected individual who has progressed to develop colon cancer using a proprietary cancer vaccine discovery platform OncoPeptVAC that the company has built. The immunogenicity of several peptides derived from somatic mutations in AXIN2, PIGO and MSH6 was validated using T cells from affected individuals, as well as HLA-matched healthy donors. Additionally, the study also analyzed the tumor microenvironment using a transcriptome-based tumor microenvironment analysis platform OncoPeptTUME, uncovering high infiltration of CD8+ T cells that lack expression of markers of activated phenotype. The potential mechanism of immune suppression, the study suggests may arise as a result of high T-regulatory cell (Treg) and myeloid-derived suppressor cell (MDSC) infiltration.
“Given that Lynch syndrome has limited treatment options, this study provides a basis for considering a cancer vaccine approach that could be used either as monotherapy or in combination with established immuno-oncology or chemotherapy drugs”, added Dr. Amit Chaudhuri, VP R&D, MedGenome and a Senior author of this study
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Source: EIN Presswire